Siegmund radlauer



UNITED STATES PATENT OEFIc SIEGRIUND RAD'LAUER, OF BERLIN, GERMANY.

SALlCYL-ANl-LED.

SPECIFICATION forming part of Letters Patent No. 526,258, dated September 18, 1894.

hp vfl h filg d March 22, 1894. Serial No. 504,599- (No specimens.)

.To all whom it may concern.-

lie it known that I, Sinonuno Rnnnnenn, chenust,ot160 FllGtll'lGllSiZitlSSfii; Berlin, in the Kingdom of Prussia and German Empire,

have invented a new and Improved Antilyretlc and AntiNeu1-algic Preparation, of

which the following is a specification.

This invention relates to a new or improved antipyretic and anti-neuralgia preparation and which is prepared by heating acetanilid with salicylic acid in approximately molecular proportions to about 100 eentigradeh The resulting oily fluid is a saline additive product ot' acetanilid and salicylic acid and has the following formula:

0,,II NIl.G lI Ofi li OlhUO lI. Upon heating this to 120 eentigrade the V desired anLi-lpyretic and anti-neuralgia product is obtained with the evolution of acetic A convenient method of carrying this invention into eitect is as folldws: One hundred parts by weight of acetanilid are thor- Oughly'mixed withonehundred and two parts by weight of salicylic acid and the mixture is heated in a steam bath to about 100- centigrade or until an oily fluid is formed. The temperature is then raised to from 120 to 150 centigradc or above, a larger quantity e1. thesalicyl-anilid being producedat the higher temperature. The product contains also .uncombined acctanilid and salicylic acid, but it is not necessary to separate the salicyl-anilid from these two substances, as they are antipyretie and antineuralgic substances, and do not disturb the medicinal eiteetof the salicylan ilid. The resulting product is then allowed to cool and forms a cake which may be pulverized or powdered. It is insoluble in water but soluble in alcohol and forms a base upon which acids can react. Its melting point is reached at about 100 centigrade.

\Vhat I claim, and desire to secure by Letters 'latcnt of the United States, is-

1. A new and improved antipyretic and anti-ueuralgie preparation consisting of salicyl-anilid, substantially as described.

2. A new and improved ant-i-pyretic and anti-neuralgic preparation consisting of salieyl-anilid, together with uncombined salicylicacid and acetanilid, substantially as de- M 

